Novel protein pseudogene

Novel protein pseudogene" (ENSG00000288567) refers to a **pseudogene**, which is a DNA segment that resembles a functional protein-coding gene but is generally nonfunctional due to sequence disruptions (such as frame shifts or premature stop codons) or lack of regulatory elements required for gene expression[1][2][3]. Pseudogenes can be created by duplication or retrotransposition but nearly always lack protein-coding capacity. While extremely rare pseudogenes may be expressed and exert regulatory or even protein functions, in almost all cases—including the general category "novel protein pseudogene"—these are nonfunctional genetic elements[2][3]. Large-scale surveys indicate pseudogenes are prevalent throughout the genome and may sometimes be misannotated as functional genes in sequence databases[2][3]. Context: - "Novel protein pseudogene" is a general genome annotation, not a specific receptor, enzyme, or molecular target. - *ENSG00000288567* is listed as a pseudogene because it shares sequence similarity to known protein-coding genes but lacks evidence for producing a functional protein[1][3]. - Pseudogenes are common in the human genome (~12,000–14,000 identified), and many are remnants of past duplication or retrotransposition events[2][3]. - They are typically not considered druggable targets or associated with established roles in disease or therapeutics, though an extremely small subset have regulatory RNA roles[4].