Novel pseudogene similar to ankyrin repeat domain 30B

ENSG00000227745 encodes a **pseudogene** annotated as "novel pseudogene similar to ankyrin repeat domain 30B". Pseudogenes are nonfunctional genomic segments similar to known protein-coding genes but typically rendered inactive by disruptions in their sequence or lack of regulatory elements[8][4]. While most pseudogenes do not encode functional proteins, some may be transcribed into non-coding RNA and can regulate the expression of related genes through various mechanisms (such as acting as miRNA sponges or by antisense interactions with parental or neighboring genes)[1][8]. However, ENSG00000227745 itself is neither a known therapeutic target nor a molecular receptor, enzyme, transporter, nor is it implicated in a specific disease or as a drug target. There are no reports of it serving as a biomarker, having known disease roles, or being associated with pharmacological activity. Because it is a pseudogene (not a functional protein-coding gene), it is not considered a therapeutic target by conventional standards, and thus its status as a target is "false"[8][4]. **Note:** There is potential confusion as there are functional ankyrin repeat domain proteins (e.g., ANKRD30B and ANKRD30A) that are protein-coding genes; however, ENSG00000227745 refers specifically to a pseudogene related to ANKRD30B, not to those functional genes[3][7][5].

Other names

ANKRD30B pseudogeneENSG00000227745pseudogene similar to ANKRD30B