novel pseudogene similar to nuclear pore associated protein 1 (ENSG00000285746)

The “novel pseudogene similar to nuclear pore associated protein 1” (ENSG00000285746; UPF0607 protein ENSP00000383144-like; LOC100129307) is a predicted pseudogene in humans, annotated by Ensembl and NCBI as non-protein-coding and mainly similar to genes encoding nuclear pore complex (NPC)–associated proteins, but not demonstrated to produce a functional protein. ENSG00000285746 (also known as UPF0607 protein ENSP00000383144-like or LOC100129307) is annotated in the human genome as a pseudogene related in nucleotide sequence to genes that encode nuclear pore–associated proteins, but there is no evidence that it produces a functional protein product. Nuclear pore complexes (NPCs) are large multi-protein structures (nucleoporins/Nups) responsible for the transport of macromolecules between the nucleus and cytoplasm and play key roles in gene regulation and cellular development[1][2][3][4]. However, this particular locus is computationally predicted and is not experimentally validated as a coding or functional NPC protein. Pseudogenes traditionally lack biological function, do not produce functional proteins, and are not considered viable direct therapeutic targets, biomarkers, or druggable proteins. This means ENSG00000285746 should not be considered a therapeutic target under standard conventions and does not have a recognized role in human disease or signaling pathways. A pseudogene is a DNA sequence similar to a gene but rendered nonfunctional due to mutations, deletions, or loss of regulatory elements. Although pseudogenes can sometimes have regulatory roles (e.g., as RNA transcripts with indirect effects), there is no such evidence for this entity. The “nuclear pore associated protein 1” itself can refer generically to nucleoporins, which have vital roles in nuclear-cytoplasmic transport and gene regulation, but this pseudogene is not functionally equivalent to those proteins[1][2][3]. If you are seeking information on actual nuclear pore proteins as drug targets, please specify the exact protein (e.g., “Nup98” or “Nup153”) for accurate molecular profiling.

Other names

UPF0607 protein ENSP00000383144-likeLOC100129307“novel pseudogene similar to nuclear pore associated protein 1”