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Novel pseudogene similar to part of integrator complex subunit 4 (ENSG00000235421)

Target
ENSG00000235421
Molecular classification
Pseudogene
01

Overview

ENSG00000235421 is a pseudogene annotated as similar to part of integrator complex subunit 4 (INTS4). As a pseudogene, it is a non-coding genomic sequence that resembles the INTS4 gene but contains disabling mutations or lacks regulatory elements necessary for protein expression, and thus does not produce a functional protein[5][6]. Pseudogenes, in general, can occasionally play regulatory roles at the RNA level, such as contributing to gene expression regulation as competing endogenous RNAs or small RNA precursors, but most remain nonfunctional, and there is no published evidence of a specific biological or clinical role for ENSG00000235421[2][4][5].

02

Biological functions

Likely none at the protein level, as pseudogenes do not encode functional proteinsPseudogenes in general can have regulatory RNA roles (such as acting as RNA sponges, antisense transcripts, or small RNA sources), but no evidence for ENSG00000235421 performing these is reported.
03

Disease associations

No established role in disease for this specific pseudogene.Pseudogenes broadly may participate in disease processes through gene regulation, but for this entry, such involvement is speculative and undocumented.

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