Novel receptor highly expressed on cancer cells

The term "Novel receptor highly expressed on cancer cells" is a generic descriptive phrase rather than a specific, canonical biological target. It is frequently used in scientific literature to introduce newly identified or emerging therapeutic targets that show high differential expression in malignant tissues compared to healthy cells. Examples of specific targets often described this way in recent oncology research include GPRC5D (G protein-coupled receptor class C group 5 member D) in multiple myeloma, ROR1 (Receptor tyrosine kinase-like orphan receptor 1) in various hematological and solid tumors, and Claudin 18.2 in gastric and pancreatic cancers. Because the phrase does not refer to a single protein, specific drug interactions, biological functions, and safety profiles cannot be definitively assigned to this entry. In a drug discovery context, this phrase typically serves as a placeholder for a target currently under investigation for high tumor-to-normal tissue expression ratios.