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Target intelligence / Profile preview
Novel ret finger protein-like 4B (RFPL4B)
- Target
- RFPL4B
- Molecular classification
- E3 ubiquitin-protein ligase (predicted), Other (not classified as enzyme, transporter, receptor, etc. by current sources)
01
Overview
RFPL4B (Novel ret finger protein-like 4B) is a predicted protein-coding gene in humans that belongs to the ret finger protein-like family. It is postulated to encode a putative E3 ubiquitin-protein ligase, likely involved in the regulation of protein stability, activity, and signaling through ubiquitination, similar to other E3 ligases. RFPL4B has predicted activity in protein homodimerization and kinase binding, with possible roles in cellular signal transduction, autophagy, and NF-κB pathway regulation. Its expression and function in cancer and human tissues has not been fully elucidated. There are no established drugs, biomarkers, or direct links to clinical conditions for RFPL4B as of 2025; further research is needed to clarify its biological and therapeutic significance.
- Other names
- RFPL4BRet finger protein-like 4B
02
Biological functions
Putative regulation of protein ubiquitination (E3 ligase activity)Protein homodimerizationProtein kinase binding
03
Disease associations
Other (no direct disease association reported for RFPL4B; family members have been implicated in cancer and chromatin remodeling, but this specific protein's role is unknown)
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