Novel retinol dehydrogenase pseudogene (ENSG00000258816)

The "novel retinol dehydrogenase pseudogene" (ENSG00000258816) is a non-functional genomic locus derived from duplication events involving retinol dehydrogenases, specifically related to the human *RDHE2* and *RDHE2S (SDR16C6)* genes. While these related genes are members of the short-chain dehydrogenase/reductase (SDR) superfamily and function in vitamin A metabolism, the pseudogene itself has lost the ability to encode a functional protein due to sequence mutations and instability. No transcripts or protein products from this locus have been characterized as biologically significant in humans. Pseudogenes, including ENSG00000258816, are generally considered “genomic fossils” and do not encode active enzymes or contribute to physiological processes.

Other names

Retinol dehydrogenase epidermal 2-similar pseudogeneRDHE2S pseudogeneSDR16C6 pseudogene

Not applicable; no mechanism of action, as no protein or function is present