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Target intelligence / Profile preview
Novel transcript, antisense to tropomyosin 1 (TPM1-AS)
- Target
- TPM1-AS
- Molecular classification
- Antisense long noncoding RNA
01
Overview
The novel transcript, antisense to TPM1 (TPM1-AS), is a long noncoding RNA that overlaps or is complementary to the protein-coding TPM1 gene (tropomyosin 1). TPM1-AS has been shown to regulate the alternative splicing of tropomyosin 1 by interacting with RNA-binding proteins such as RBM4, modulating the isoform expression profile of TPM1. Through these regulatory mechanisms, TPM1-AS can influence actin cytoskeleton organization, cell shape, adhesion, migration, and potentially cardiac development and cancer progression. However, TPM1-AS is not a receptor, enzyme, transporter, or conventional drug target, and no approved drugs are known to interact directly with this transcript.
- Other names
- TPM1-ASNatural antisense transcript TPM1-AS
02
Biological functions
Regulation of alternative splicing (of TPM1)Modulation of cytoskeletal organization (indirect effect through TPM1 regulation)Possible roles in cell adhesion and migration (if altering TPM1 expression)
03
Disease associations
May influence cardiac development (indirect, via TPM1)Cancer (modulates TPM1 tumor suppressor functions and influences cytoskeletal remodeling)
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