Novel transcript, antisense to ANKRD54 and SYN3 (ENSG00000299801)

This entry refers to a long non-coding RNA (lncRNA) identified as a "novel transcript, antisense to ANKRD54 and SYN3," annotated in genomic databases such as Ensembl with the gene ID ENSG00000299801[1]. As a natural antisense transcript (NAT), it is transcribed from the opposite DNA strand relative to the protein-coding ANKRD54 and SYN3 genes and may partially overlap them at the nucleotide level. NATs like this can exert diverse regulatory effects on their sense gene partners, including transcriptional interference (colliding RNA polymerases result in reduced gene expression), RNA masking (impairing splicing or translation), and involvement in epigenetic regulation via chromatin modifications[2][4]. While the broad class of NATs has been implicated in gene expression regulation and some disease contexts, there is no direct evidence indicating therapeutic relevance, disease implication, or druggability for this specific transcript as of the current data[3]. Its functional annotation remains limited, and it is not currently considered a therapeutic target in pharmacology or medicine.

Other names

SYN3-AS1lncRNA novel transcript antisense to ANKRD54 and SYN3[1]