Novel transcript, antisense to Calmodulin 3 (ENSG00000269292 (no well-established abbreviation))

A novel antisense transcript at the CALM3 (calmodulin 3) locus, identifiable as ENSG00000269292, is likely a long non-coding RNA that is transcribed opposite to the CALM3 gene. Antisense transcripts can regulate gene expression at the level of transcription, chromatin accessibility, RNA processing, and stability. While antisense RNAs are increasingly recognized as regulatory molecules and putative drug targets, there is currently no evidence that this particular antisense transcript is a validated therapeutic target or is implicated in specific diseases. CALM3 itself encodes calmodulin, a calcium-binding protein essential for cell signaling, cycle control, and cytokinesis. Antisense modulation at the CALM3 locus may theoretically influence CALM3 protein levels and function, as demonstrated for other calmodulin genes (e.g., CALM1), with potential therapeutic utility in calmodulinopathies, but specific functional or clinical annotations for ENSG00000269292 are lacking. If structured information is later required for drug or target databases, this transcript should be classified as a non-coding antisense transcript at the CALM3 locus, with minimal evidence of direct therapeutic targeting or disease association as of 2024.

Other names

ENSG00000269292Antisense to Calmodulin 3Non-coding antisense transcript at CALM3 locus

Modulation of gene expression via base-pairing with CALM3 mRNA, affecting its stability, splicing, or translation (general antisense mechanism); Chromatin modification and transcriptional interference (general antisense transcript effects)