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Novel transcript, antisense to GRIN2A and RP11-89D3.2

Molecular classification: Long non-coding RNA (lncRNA)

Overview

ENSG00000302122 encodes a long non-coding RNA known as "Novel transcript, antisense to GRIN2A and RP11-89D3.2." This lncRNA is transcribed antisense to the GRIN2A gene locus and may play a regulatory role affecting the expression of GRIN2A, a gene encoding an NMDA receptor subunit involved in neuronal signaling and implicated in epilepsy and related neurodevelopmental disorders[3][4][2]. Antisense lncRNAs like this one can modulate gene expression through mechanisms such as transcriptional interference, chromatin remodeling, or mRNA stability, but the specific function and biological impact of ENSG00000302122 have not been established[6][1].

Other names: Antisense to GRIN2A and RP11-89D3.2may also be referred to as a lncRNA related to these loci[3][4]

Biological functions

Regulation of neighboring gene expression (notably GRIN2A, which encodes a subunit of the NMDA receptor)Chromatin modification or epigenetic regulation via antisense transcription[6][1]

Disease associations

Other (specific disease associations not established for this particular lncRNA)Potential indirect involvement if it regulates GRIN2A, which is implicated in epilepsy and neurodevelopmental disorders[2]

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