Novel transcript, antisense to integrin alpha-6

ENSG00000295985 is a long non-coding RNA (lncRNA) annotated as a "novel transcript, antisense to integrin alpha-6 (ITGA6)". This lncRNA, also referred to in some literature as ITGA6-AS1, is transcribed from the opposite DNA strand overlapping exon 2 of the protein-coding ITGA6 gene. Antisense RNAs such as this transcript may regulate their sense gene targets through mechanisms that alter mRNA stability or translation, including sequence-specific interactions in exons or untranslated regions (UTRs). In the case of ITGA6-AS1, evidence suggests it may partially pair with ITGA6 mRNA in the 3′ UTR or exon 2, potentially affecting ITGA6 expression in human mesenchymal stem cells, with resulting impacts on stem cell proliferation and fate[1][5]. However, ENSG00000295985 is not a well-characterized protein-coding gene or a recognized drug target such as a receptor, enzyme, or transporter, and is not considered a canonical therapeutic target[5]. Many databases simply list it as a putative lncRNA with limited functional annotation.

Other names

ENSG00000295985ITGA6-AS1 (putative antisense lncRNA overlapping ITGA6)

May regulate ITGA6 via antisense RNA-mediated mechanisms, including partial base pairing in ITGA6 exon 2 and 3′ UTR, possibly affecting mRNA stability[1]