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Novel transcript, antisense to neuropilin-1
- Molecular classification
- Other (long non-coding RNA, antisense transcript)
01
Overview
ENSG00000238258 is an uncharacterized or \"novel\" antisense long non-coding RNA transcript transcribed from the genomic region antisense to the neuropilin-1 (NRP1) gene. Antisense lncRNAs can regulate the expression of neighboring protein-coding genes such as NRP1 through several mechanisms, including transcriptional interference, chromatin remodeling, mRNA stability modulation, or effect on alternative splicing[2]. However, most antisense lncRNAs, especially those labeled as \"novel transcripts\" in genome annotations, have uncertain or unvalidated biological roles. There is no evidence supporting ENSG00000238258 as a receptor, enzyme, transporter, or other conventional therapeutic target, nor is it currently recognized in disease pathogenesis or as a direct biomarker. If you are interested in druggable targets for angiogenesis, immunity, or infection, the protein product NRP1 (neuropilin-1), not its antisense lncRNA, would be the canonical target[1][3].
- Other names
- ENSG00000238258antisense to NRP1
02
Biological functions
Possible gene regulation (cis or trans regulation of NRP1 or nearby genes); could impact mRNA stability, alternative splicing, or chromatin state[2]
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