Novel transcript, antisense to Ring Finger Protein 138 (None established; ENSG00000265008 is a genome annotation ID)

The "novel transcript, antisense to RNF138" (ENSG00000265008) is an annotated non-coding RNA transcribed antisense to the RNF138 gene. Antisense non-coding RNAs are widely distributed in genomes and can regulate the corresponding sense transcript by modifying chromatin state, transcription rates, and mRNA processing, typically through mechanisms involving interference or epigenetic modulation[2][4]. No experimental data are available to link this particular transcript to a defined biological or pathological process, nor to any existing drug, biomarker, or safety concern. Unlike the protein-coding RNF138 gene (an E3 ubiquitin ligase involved in DNA double-strand break repair[5]), the antisense transcript lacks an open reading frame and is not known to encode any functional protein. This transcript may reflect a general phenomenon of antisense regulation, where such RNAs alter the chromatin environment or stability of paired sense mRNAs, but no specific functional or disease-related data exist for ENSG00000265008 itself[2][4].

Other names

ENSG00000265008 (Ensembl gene ID)Novel antisense transcript to RNF138

None known. Antisense non-coding RNAs principally act via regulation of sense transcript production and processing, chromatin modification, and mRNA stability.