Novel transcript, antisense to ROBO2 (ENSG00000287567)

Novel transcript, antisense to ROBO2 is a natural antisense, non-protein-coding RNA transcribed from the DNA strand opposite the ROBO2 gene and partially overlaps with it. Antisense transcripts such as this are prevalent in mammalian genomes and most often function to regulate their partner sense genes at the transcriptional or post-transcriptional level. These functions may include influencing the sense gene's mRNA stability, splicing, nuclear export, or local chromatin structure. The specific functions of this antisense transcript in relation to ROBO2 have not been experimentally determined, but by analogy to other antisense RNAs, it may participate in fine-tuning ROBO2 expression via RNA-RNA interactions, recruitment of chromatin-modifying enzymes, or masking functional elements on the ROBO2 mRNA[2][3]. This molecule is not generally regarded as a therapeutic target such as a receptor or enzyme. There are no drugs known to act on this transcript, nor has it been reported as a biomarker or safety concern. The vast majority of natural antisense RNAs are not targets for small-molecule drugs, but may serve regulatory roles in gene expression relevant to cell differentiation, development, or gene silencing[2][3]. The functionality of antisense transcripts is diverse and locus-specific. Effects may be positive or negative on the paired sense gene and can involve varied mechanisms, including epigenetic modification, RNA masking, or involvement in RNA stability pathways[2][3].

Other names

Antisense to ROBO2ROBO2-AS (inferred common aliasing convention for antisense RNAs)