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Novel transcript, antisense to TANC2 (ENSG00000263501)
- Target
- ENSG00000263501
- Molecular classification
- Other (long non-coding RNA, natural antisense transcript)
01
Overview
This target is a long non-coding RNA (lncRNA) known as a cis-natural antisense transcript, transcribed from the opposite DNA strand overlapping the TANC2 gene. It does not encode a protein and instead modulates the function of the TANC2 gene, likely through epigenetic changes (modifying chromatin structure) and/or by regulating transcript stability of TANC2. While the sense gene TANC2 is a scaffolding protein involved in synaptic development and has disease associations in neurodevelopmental disorders, the specific functional role of this antisense transcript remains unclear, apart from general roles in gene regulation associated with antisense lncRNAs[1][3][6].
- Other names
- Novel transcript, antisense to TANC2ENSG00000263501
02
Biological functions
Regulation of gene expression (via antisense transcription effects on the TANC2 sense transcript)Epigenetic regulation (modifies chromatin near TANC2 locus)
03
Disease associations
Other (potentially involved in the regulation of TANC2, which is associated with neurodevelopmental disorders, but this specific antisense transcript's disease role is unestablished)
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