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Novel transcript, antisense to titin (AC009948.1)
- Target
- AC009948.1
- Molecular classification
- lncRNA, natural antisense transcript (NAT)
01
Overview
Novel transcript, antisense to titin" (ENSG00000270277) is a long non-coding RNA identified in the human genome, transcribed from the antisense strand of the Titin (TTN) gene locus on chromosome 2[1][2][3][6]. Antisense lncRNAs at the titin locus are increasingly recognized for their regulatory roles in TTN mRNA splicing and potentially in cardiac physiology[5]. Disruption or modulation of certain antisense transcripts may affect titin protein isoform expression and sarcomere function, especially in heart failure and cardiomyopathy[4][5]. However, there is presently no clinical evidence supporting this transcript as a validated therapeutic target, biomarker, or as being associated with specific disease roles, though ongoing research in RNA regulation in cardiomyopathy suggests emerging potential in RNA-based intervention for titin-related pathologies[4][5].
- Other names
- AC009948.1ENSG00000270277
02
Biological functions
Regulation of alternative splicing of titin mRNA (shown for some titin antisense transcripts like TTN-AS1-276, but not yet specifically mapped to this transcript)Modulation of sarcomere properties (by regulatory action on titin splicing, per NAT studies)
03
Disease associations
Other (Indications that antisense transcripts may influence heart diseases by affecting titin splicing, e.g. in heart failure. However, this specific transcript is not implicated in major diseases yet.)
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