Novel Triggering Receptor Expressed on Myeloid Cells (TREM) Family Member (Novel TREM Receptor)

A newly identified or characterized cell surface receptor belonging to the TREM family, expressed on antigen-presenting cells (APCs) such as dendritic cells and macrophages, as well as some lymphoid cells. It acts as an activating receptor, enhancing antigen presentation capabilities and modulating downstream immune responses upon ligand binding. Downstream signaling involves adapter proteins like DAP12, leading to phosphorylation cascades and gene transcription relevant for inflammation or tolerance. Understanding its specific ligands and signaling pathways could have implications for vaccine development and modulating autoimmune responses.

Other names

Novel Activating Receptor on APCsNovel TREM-family ReceptorTREM Receptor on Dendritic Cells

Ligand binding induces activation signals via adapter proteins (e.g., DAP12) leading to phosphorylation cascades and gene transcription relevant for inflammation or tolerance.