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NPSR1 antisense RNA 1 (NPSR1-AS1)
- Target
- NPSR1-AS1
- Molecular classification
- Antisense RNA, Long non-coding RNA (lncRNA), Other (non-protein-coding RNA)
01
Overview
NPSR1 antisense RNA 1 is a non-protein-coding RNA gene located on chromosome 7p14.3. It is an antisense transcript to the NPSR1 (neuropeptide S receptor 1) gene and exhibits alternative splicing. NPSR1-AS1 may play a role in gene regulation and disease susceptibility, particularly asthma, due to its genomic proximity and regulatory interactions with NPSR1. Unlike NPSR1, it does not produce a protein but is a member of the long non-coding RNAs, which are increasingly recognized for their roles in gene expression modulation and disease development. There is evidence linking genetic variants within this locus to asthma and immune phenotypes such as serum cholesterol and thyroid antibodies.
- Other names
- AAA1IMAGE:4827585asthma-associated alternatively spliced gene 1NPSR1 antisense RNA 1 (non-protein coding)
02
Biological functions
Gene regulation (especially linked to the nearby NPSR1 gene)Alternative splicingPotentially modulating disease susceptibility
03
Disease associations
Asthma susceptibility (the genomic region is associated with risk for asthma)Potential involvement in immune-related traitsCholesterol measurement associationsThyroid antibody measurement associations
04
Biomarkers
rs325465 (associated with serum total cholesterol measurement)rs323907 (associated with thyroglobulin antibody measurement)
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