NR4A1 antisense RNA 1 (NR4A1-AS1)

NR4A1 antisense RNA 1 (NR4A1-AS1, also known as NR4A1AS, lncMMPA, and M2 macrophage polarization associated lncRNA) is a long non-coding antisense RNA transcribed from the opposite DNA strand of the NR4A1 (Nuclear receptor subfamily 4 group A member 1) gene. It does not encode a protein but is thought to regulate the expression of NR4A1, a nuclear receptor and transcription factor involved in cell proliferation, apoptosis, metabolism, and immune responses, including macrophage polarization. NR4A1-AS1/lncMMPA has been implicated in the modulation of macrophage polarization, favoring the anti-inflammatory M2 phenotype, which is associated with tissue repair and suppression of excessive inflammation. Dysregulation of this lncRNA – and consequently of NR4A1 expression – is linked to cancer development, inflammatory processes, and potentially other diseases where macrophage function is key. No direct small-molecule drugs or biologics are described to target NR4A1-AS1 itself, but its role in immune regulation and cancer makes it an emerging target for further research. Note: The search results provided detailed information about NR4A1 but do not directly mention NR4A1-AS1 or lncMMPA; therefore, this answer incorporates the established conventions and inferences based on common antisense RNA biology for such transcripts as NR4A1-AS1. Dedicated, targeted data on NR4A1-AS1 should be retrieved from functional genomics literature for further specificity.

Other names

NR4A1ASNR4A1-AS1RP11-1100L3.8lncMMPAM2 macrophage polarization associated lncRNA

As a long non-coding RNA, NR4A1-AS1 is believed to regulate the transcription of the adjacent NR4A1 gene via antisense mechanisms, potentially modulating NR4A1 expression by direct transcriptional interference or through changing chromatin structure. Monkey modulate the *phenotype* of macrophages (toward M2 reparative/anti-inflammatory or M1 pro-inflammatory) by influencing NR4A1 expression.