Target intelligence / Profile preview

NR7 receptor (NR7)

Target: NR7
Molecular classification: Transcription factor, Nuclear receptor

Overview

NR7 represents an ancient nuclear receptor subfamily found in amphioxus (*Branchiostoma lanceolatum*), characterized by constitutive transcriptional activation and DNA-dependent heterodimerization with RXR—a mechanism distinct from more classical nuclear receptors that operate independently of DNA presence. It is considered a missing link in the transition between class I and class II nuclear receptors.

Other names: Nuclear receptor subfamily 7

Mechanism of action

Constitutive transcriptional activation and DNA-dependent heterodimerization with RXR.

Biological functions

Transcriptional regulationheterodimerization with retinoid X receptor (RXR)DNA-dependent dimerization

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