NRG3 antisense RNA 1 (NRG3-AS1)

**NRG3 antisense RNA 1 (NRG3-AS1)** is a long non-coding RNA (lncRNA), transcribed in the antisense direction to the NRG3 gene. It is classified as a natural antisense transcript and does not code for a protein[2][7]. Antisense RNAs, such as NRG3-AS1, can regulate the expression of their sense partners (here, NRG3) through several mechanisms, including chromatin remodeling, transcriptional interference, or modifying RNA stability or translation[3][6]. These molecules may act in cis (affecting nearby genes on the same chromosome) or in trans (at distant genomic locations), and often function in the regulation of gene expression at multiple stages. However, as of the current literature and gene databases, there is **no specific evidence that NRG3-AS1 is a validated therapeutic target, biomarker, or has disease association, nor are there drugs known to interact with or target NRG3-AS1**[2][7]. NRG3-AS1 may play regulatory roles in the central nervous system or other tissues, largely through non-coding RNA mechanisms typical for antisense transcripts, but its precise functions as of now are not clearly characterized in the biomedical literature[2][3][7].

Other names

C10orf100Em:AC010157.1NRG3 antisense RNA 1 (non-protein coding)