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Target intelligence / Profile preview
NRXN1 divergent transcript (NRXN1-DT)
- Target
- NRXN1-DT
- Molecular classification
- Long non-coding RNA (lncRNA), Other
01
Overview
NRXN1 divergent transcript (NRXN1-DT, also known as AK127244) is a long non-coding RNA located adjacent to the promoter of the Neurexin 1 (NRXN1) gene. Genomic deletions involving NRXN1-DT have been associated with neuropsychiatric disorders, including autism spectrum disorder and schizophrenia. The biological function of NRXN1-DT remains unknown, although its expression pattern in the brain suggests a putative role in neurodevelopmental processes. Presently, NRXN1-DT is not considered a therapeutic target, and no drugs are known to interact with this transcript[1].
- Other names
- AK127244NRXN1-DT
02
Mechanism of action
Not applicable (no described mechanism for drug action on this transcript)
03
Biological functions
UnknownPutative role in neurodevelopmental regulation (speculative, based on association with neurodevelopmental disorders)
04
Disease associations
Neuropsychiatric disordersDevelopmental delay/intellectual disability (DD/ID)Autism spectrum disorder (ASD)
05
Safety considerations
Not established; as there are no drugs targeting this lncRNA, specific safety concerns are not defined
06
Biomarkers
Deletions or copy number variants overlapping NRXN1-DT/AK127244 may have utility as genomic biomarkers for neuropsychiatric risk in select cases
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