NRXN3 antisense RNA 2 (NRXN3-AS2)

NRXN3 antisense RNA 2 (NRXN3-AS2) is a long non-coding RNA (lncRNA) transcribed in the antisense orientation to the NRXN3 (Neurexin 3) gene locus. Like many antisense RNAs, it does not code for a protein, but may regulate the expression or splicing of the associated NRXN3 gene, which encodes an important synaptic cell adhesion protein involved in neurotransmission. While the precise biological functions of NRXN3-AS2 are not fully elucidated, it may play a role in neural gene regulation through transcriptional and post-transcriptional mechanisms. There are no reported drugs, biomarker uses, or established roles as a therapeutic target for NRXN3-AS2 itself. Important context: NRXN3-AS2 is distinct from Neurexin 3 (NRXN3), which is a synaptic cell surface receptor and active drug and disease target. NRXN3 itself is involved in synaptic organization and is associated with disorders such as autism and addiction. As an ncRNA, NRXN3-AS2 should not be confused with protein-coding targets, enzymes, or classical receptors. There is no evidence that NRXN3-AS2 is a direct disease biomarker, therapeutic target, or pharmacological receptor. If you intended information about the protein-coding Neurexin 3 (NRXN3), which is a recognized therapeutic target, please clarify. Otherwise, by strict naming, NRXN3-AS2 refers to the non-coding antisense RNA.

Other names

NRXN3-AS2NRXN3 antisense RNA 2