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NS5B RNA-dependent RNA Polymerase (None)

Target: None
Molecular classification: Enzyme, RNA-dependent RNA polymerase

Overview

NS5B is a nonstructural protein of the hepatitis C virus (HCV) that functions as an RNA-dependent RNA polymerase (RdRp). Its primary role is to catalyze the replication of HCV's viral RNA genome by using the positive-sense viral RNA strand as a template, facilitating the polymerization of ribonucleoside triphosphates (rNTPs) during this process. It is a major antiviral drug target because inhibiting it halts HCV genome replication.

Mechanism of action

Inhibition of viral RNA replication by nucleotide analogue incorporation and chain termination or allosteric modulation.

Biological functions

Viral genome replicationrNTP polymerization

Disease associations

InfectionHepatitis C

Interacting drugs

Sofosbuvir

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