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Target intelligence / Profile preview
NSA2 ribosome biogenesis factor (NSA2)
- Target
- NSA2
- Molecular classification
- Other (ribosome biogenesis factor), Nucleolar protein
01
Overview
NSA2 ribosome biogenesis factor is a highly conserved nucleolar protein involved in the assembly and biogenesis of the large (60S) ribosomal subunit[1][3]. It is essential for cell cycle regulation and cell proliferation. NSA2 is not considered a classic therapeutic target such as a receptor, enzyme, or transporter; rather, it is one of several ribosome biogenesis factors necessary for proper ribosome assembly. Increased expression of NSA2 has been observed in certain disease states, such as diabetic nephropathy. Multiple alternative splice variants and pseudogenes have been identified for NSA2[1][3]. The protein may play a role in the quality control of pre-60S ribosomal particles, but no direct drug targeting or clinical biomarker usage is currently described[3].
- Other names
- TINP1HCL-G1CDK105HUSSY-29HUSSY29HCLG1
02
Biological functions
Ribosome biogenesis (specifically 60S ribosomal subunit assembly)Cell cycle regulationCell proliferationRNA binding
03
Disease associations
Cancer (e.g., reported in lateral ventricle meningioma)Diabetic nephropathy (elevated levels reported)AlopeciaNeurologic defectsEndocrinopathy syndrome
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