NT5C1B-RDH14 readthrough (NT5C1B-RDH14)

NT5C1B-RDH14 readthrough is a naturally occurring chimeric transcript and protein resulting from read-through transcription between the NT5C1B (5′-nucleotidase, cytosolic IB) gene and RDH14 (retinol dehydrogenase 14) gene on chromosome 2. The readthrough encodes a fusion protein that contains sequence from both parent genes; the main known functional domains are nucleotide binding and potential magnesium ion binding, derived from the NT5C1B component. This fusion has no established role as a therapeutic target, receptor, or druggable protein, and there is no evidence of specific disease involvement or biomarker utility for this readthrough product. The functional significance is poorly defined, and most research attributes biological and disease relevance to the individual parent genes rather than the read-through product itself[2][6][5].

Other names

AIRPNT5C1BcN-IBcN1BNT5C1B-RDH14 proteinCytosolic 5'-nucleotidase 1BCytosolic 5'-nucleotidase IBNT5C1B-RDH14 read-through transcriptNT5C1B-RDH14