Nuclear casein kinase and cyclin-dependent kinase substrate 1 (NUCKS1)

Nuclear casein kinase and cyclin-dependent kinase substrate 1 (NUCKS1) is a highly conserved, chromatin-associated nuclear protein in vertebrates, encoded by the *NUCKS1* gene on chromosome 1q32.1[3][4][5]. NUCKS1 contains consensus phosphorylation sites for casein kinase II (CK2) and cyclin-dependent kinases (CDKs), and is subject to multiple post-translational modifications including phosphorylation, acetylation, methylation, and ubiquitylation[4]. Structurally and functionally similar to the high-mobility group (HMG) protein superfamily, NUCKS1 regulates chromatin architecture, participates in transcriptional control, and is essential for genome stability through its role in DNA repair, particularly in promoting homologous recombination[2][4][6][8][10]. NUCKS1 is involved in pivotal cellular processes such as cell cycle regulation, DNA damage response, metabolic control (e.g., insulin pathway regulation), and modulation of immune/inflammatory responses[2][4][6]. Dysregulation or altered expression of NUCKS1 has been implicated in a spectrum of pathologies, especially various cancers, metabolic syndrome, neurodegenerative diseases like Parkinson’s, and mood disorders, where it may act as a prognostic biomarker or contributor to disease etiology[4][2][6]. As of now, there are no known small molecules or drugs that specifically target NUCKS1, and it is not an established druggable therapeutic target[4][10].

Other names

Nuclear casein kinase and cyclin-dependent kinase substrate 1Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1NUCKSJC7P1potential LAG1 interactor

Not applicable; no targeted drugs identified