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Nuclear distribution protein C (NUDC)
- Target
- NUDC
- Molecular classification
- Other (mitotic protein, chaperone-like, spindle assembly factor; not classified as receptor, enzyme, transporter, channel, or transcription factor)
01
Overview
**Nuclear distribution protein C (NUDC)** is a conserved intracellular protein essential for correct mitosis and cytokinesis, where it is required for mitotic spindle formation, chromosome segregation, microtubule organization, and completion of cell division[1][2][3][6]. It also has documented roles in cell proliferation, neurogenesis, neuronal migration, and possibly cellular stress response and protein folding via chaperone-like activities[1][2][6]. NUDC is not a receptor, enzyme, or transporter, but rather a regulatory and scaffolding factor within the dynein motor complex and cytoskeletal processes[1][2][3][6]. Its dysfunction is linked to developmental abnormalities, such as lissencephaly, and it is under continued investigation for roles in cancer and neurodevelopmental disease[1][3].
- Other names
- Nuclear migration protein nudCNUDCNuclear distribution protein C homologHNUDCMNUDCNPD011nuclear migration protein nudCnuclear distribution gene C homolognudC nuclear distribution protein
02
Biological functions
Cell divisionMitosisCytokinesisCell proliferationNeurogenesisNeuronal migrationMicrotubule organizationProtein foldingNuclear migration and positioningIntracellular transportStress response
03
Disease associations
Cancer (implicated through cell proliferation/mitosis)Neurodevelopmental disorders (e.g. lissencephaly)Body mass index traits
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