Nuclear distribution protein nudE homolog 1 (NDE1)

Nuclear distribution protein nudE homolog 1 (NDE1) is a centrosomal scaffold/adaptor protein vital for neurodevelopment, especially cortical brain formation. It governs centrosome duplication, mitotic spindle formation, and the organization and orientation of microtubules during cell division, particularly in neural progenitors[1][3][5]. By controlling the axis of cell division, it influences the balance between neural progenitor expansion and differentiation, affecting total neuron numbers and cortical layering[1][3][5]. NDE1 interacts with LIS1 and dynein to regulate nuclear migration and mitotic spindle formation, and with chromatin modifiers to safeguard genome integrity during S phase, preventing DNA damage in developing neurons[2][4][5]. Loss-of-function mutations in both alleles cause severe developmental brain disorders such as lissencephaly with microcephaly, while heterozygous loss may raise cancer risk[2][3]. NDE1 is not currently considered a classical drug target (receptor, enzyme, transporter), but is instead a key player in cell architecture and genome safeguarding during neurodevelopment[1][3][5].

Other names

NDE1NUDENudEFLJ20101NDEHOM-TES-87LIS4MHACNUDE1LIS1-interacting protein NUDE1