Nuclear distribution protein nudE-like 1 (NDEL1)

Nuclear distribution protein nudE-like 1 (NDEL1) is a conserved scaffold protein encoded by the NDEL1 gene in humans, essential for intracellular transport and cell division[1]. It primarily regulates the dynein motor complex by binding both dynein and its cofactor LIS1, thereby facilitating microtubule-based vesicular and organelle transport and supporting proper mitotic spindle positioning. NDEL1 is highly expressed in the brain, where it orchestrates neuronal precursor proliferation, migration, and maturation—key processes during neurodevelopment[2][3][5]. Phosphorylation of NDEL1 by kinases such as DYRK2 and GSK3β modulates its function in neuronal morphogenesis and cytoskeletal dynamics[2]. Loss of NDEL1 function in animal models leads to embryonic lethality and severe neurodevelopmental defects, implicating it in human neurodevelopmental and neuropsychiatric disorders including schizophrenia[2][3]. Although NDEL1 is not a conventional therapeutic target like a receptor or enzyme, it is functionally critical for nervous system development and its disruption is associated with disease.

Other names

Endooligopeptidase AProtein NudelMitosin-associated protein 1EOPAMITAP1NDE1L1NDE2NUDEL