Nuclear envelope pore membrane protein POM 121B (POM121B)

Nuclear envelope pore membrane protein POM 121B (POM121B) is an integral transmembrane protein and a structural component of the nuclear pore complex (NPC), mediating nuclear-cytoplasmic transport by anchoring key nucleoporin subcomplexes to the nuclear envelope[1][2][3][4][5]. POM121B possesses an N-terminal membrane-spanning domain, nuclear localization signals that facilitate nuclear targeting through importin-α/β, and C-terminal FG repeats that assist in molecular trafficking across the NPC[4][5]. It is indispensable for NPC assembly during interphase and interacts with scaffold NPC proteins such as Nup155 and Nup160[2][3]. POM121B has been implicated in cancer, both as a gene fusion partner and by mediating oncogenic transport into the nucleus[1]. Though not a therapeutic target in the conventional sense (e.g., receptor or enzyme), its role is essential for nuclear architecture and cell viability[1][2][3][4].

Other names

Putative nuclear envelope pore membrane protein POM 121BPOM121BPOM121