Nuclear exosome regulator NRDE2 (NRDE2)

Nuclear exosome regulator NRDE2 (*NRDE2*) is an evolutionarily conserved nuclear RNA-binding protein and splicing factor originally discovered in *Caenorhabditis elegans* for its role in nuclear RNA interference and heritable gene silencing[2][3]. In humans, NRDE2 localizes mainly to nuclear speckles, where it regulates pre-mRNA splicing by suppressing intron retention in transcripts with short, GC-rich introns and weak splice sites[2][3]. It forms a 1:1 complex with the RNA helicase MTR4, inhibiting MTR4 recruitment and interaction with the nuclear exosome, thus limiting exosome-mediated RNA degradation and ensuring efficient mRNA nuclear export and stability[1][2][3]. NRDE2 interacts with components of the U5 small nuclear ribonucleoprotein (snRNP), the exon junction complex (EJC), and the RNA exosome, and is required for the proper expression and splicing of key mitotic proteins such as CEP131, which contributes to centrosome maturation and genome stability[2][3][1]. Depletion or loss of NRDE2 results in increased genomic instability, DNA damage, and mitotic defects, but no direct role in disease or established therapeutic drug targeting has been confirmed to date[2][3][1].

Other names

NRDE2C14orf102FLJ14051Protein NRDE2 homologUPF0614 protein C14orf102NRDE-2nuclear RNAi defective 2

Not applicable; no known drugs directly target NRDE2 as a therapeutic mechanism