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Target intelligence / Profile preview
Nuclear Factor Erythroid 2–Related Factor 2 (NRF2)
- Target
- NRF2
- Molecular classification
- Transcription Factor, Basic Leucine Zipper Protein, Cap ‘n’ Collar Subfamily
01
Overview
Nuclear factor erythroid 2–related factor 2 (NRF2) is a master transcription factor that plays a central role in cellular defense against oxidative and electrophilic stress. It regulates the expression of antioxidant proteins and cytoprotective enzymes by binding to antioxidant response elements (AREs) in the promoter regions of target genes.
- Other names
- NFE2L2nuclear factor erythroid-derived 2-like 2
02
Mechanism of action
Upregulation of antioxidant and detoxification genes via binding to antioxidant response elements (AREs).
03
Biological functions
Regulation of antioxidant gene expressionRegulation of detoxification gene expressionControl of redox homeostasisInduction of cytoprotective enzymesRegulation of autophagyRegulation of proteostasisRegulation of mitochondrial functionRegulation of inflammationRegulation of immune responsesRegulation of metabolic homeostasis
04
Disease associations
Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS)Chronic Obstructive Pulmonary Disease (COPD)Idiopathic Pulmonary Fibrosis (IPF)Asthma/Allergy disordersNeurodegenerative diseasesCancer chemoresistanceMetabolic syndromesOxidative Stress related diseasesInflammation
05
Safety considerations
Potential for off-target effects due to broad regulatory role.Possible disruption of cellular homeostasis with excessive activation.
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