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Target intelligence / Profile preview
Nuclear factor Erythroid-derived 2-like 2 pathway
- Molecular classification
- Transcription factor pathway, Signaling pathway
01
Overview
The Nrf2 pathway is a crucial cellular defense mechanism against oxidative and electrophilic stress. Activation of the Nrf2 pathway leads to the transcription of a wide array of cytoprotective genes involved in antioxidant responses, detoxification, and maintenance of redox homeostasis. Dysregulation of the Nrf2 pathway is implicated in various diseases, including cancer, cardiovascular disease, and neurodegenerative disorders.
- Other names
- Nrf2-ARE pathwayNFE2L2 pathwayAntioxidant Response Element pathway
02
Mechanism of action
Activation of ARE-dependent gene expression
03
Biological functions
Antioxidant defenseDetoxificationRedox homeostasisAutophagy modulationMetabolism regulationStem cell quiescenceUnfolded protein response
04
Disease associations
CancerCardiovascular diseaseNeurodegenerative diseaseRespiratory diseasesInflammationOxidative stress-related pathologies
05
Safety considerations
Potential pro-tumorigenic effects in certain cancer contextsOff-target effects due to broad cytoprotective activityComplex interactions with other signaling pathways
06
Biomarkers
NQO1 expressionHO-1 expressionGCL expression
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