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Target intelligence / Profile preview
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)
- Target
- NF-κB
- Molecular classification
- Transcription factor
01
Overview
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is an evolutionarily conserved family of transcription factors critical for immune regulation, inflammation control, cellular growth/apoptosis decisions—and whose dysregulation contributes directly to cancer progression as well as autoimmune/inflammatory pathologies.
- Other names
- NFκBNF-kappaBNuclear factor kappa B
02
Mechanism of action
NF-κB inhibitors block the activation of NF-κB, preventing its translocation to the nucleus and subsequent gene transcription.
03
Biological functions
Innate and adaptive immunityInflammatory responsesCell proliferationApoptosisSynaptic plasticityMemory formationCytokine productionRegulation of gene expression
04
Disease associations
CancerAutoimmune diseasesInflammatory diseasesAtherosclerosisSeptic shockViral infections
05
Safety considerations
Increased risk of infection due to immunosuppressionPotential for off-target effects due to broad role in cellular processes
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