Target intelligence / Profile preview

Nuclear Factor Kappa-B Essential Modulator (NEMO)

Target: NEMO
Molecular classification: Regulatory protein, Scaffolding protein

Overview

NEMO (NF-κB Essential Modulator), also known as IKKγ, is a regulatory subunit of the IKK complex, crucial for activating the NF-κB transcription factor. It acts as a scaffolding protein, recruiting and organizing kinases to facilitate phosphorylation events leading to NF-κB activation, thereby controlling genes involved in inflammation, immunity, cell survival, and other processes. Mutations in the IKBKG gene, encoding NEMO, cause immunodeficiency syndromes and can contribute to inflammatory disorders or cancer.

Other names: Inhibitor of nuclear factor kappa-B kinase subunit gammaIKK-γIKBKG

Mechanism of action

N/A

Biological functions

NF-κB signalingImmune responseInflammationCell survivalStress responseCytokine production

Disease associations

ImmunodeficiencyInflammatory disordersCancer

Safety considerations

Aberrant NF-κB activationIncreased susceptibility to infections

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