Nuclear factor kappa-B p100 subunit (NFKB2 (also known as NF-κB2 or p100))

Nuclear factor kappa-B p100 subunit is a member of the NF-kappa-B family encoded by the *NFKB2* gene. It functions primarily as a transcription factor involved in regulating genes critical for immunity, inflammation, cell survival, proliferation, and apoptosis. The protein exists initially as a precursor called **p100**, which can be processed into an active form known as **p52**, participating either as an activator or repressor depending on dimerization partners. Activation occurs via both canonical and non-canonical pathways involving various stimuli such as cytokines and stress signals. Mutations affecting this protein are linked to primary immunodeficiencies like CVID and rare syndromes involving combined endocrine/immune dysfunctions. Its central role makes it both an attractive but challenging therapeutic target due to potential systemic effects when modulated pharmacologically[1][3].

Other names

NFKB2NF-kappa-B2NF-κB2p100 (precursor form)p52 (processed form)

Drugs targeting this molecule would typically: inhibit or modulate its processing from p100 to p52 to alter downstream gene expression; block nuclear translocation of active complexes; modulate upstream kinases such as IKKs that regulate its activation state; affect dimerization with other Rel family members to change transcriptional outcomes.