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Target intelligence / Profile preview
Nuclear Factor Kappa B Subunit 2 (NFKB2)
- Target
- NFKB2
- Molecular classification
- Transcription factor
01
Overview
Nuclear factor kappa B subunit 2 (NFKB2) is a key component of the NF-κB transcription factor complex, regulating genes involved in inflammation, immune function, and cell survival. The protein, processed from the p100 precursor to p52, functions as a transcriptional activator or repressor depending on its dimerization partner. Mutations in NFKB2 are associated with common variable immunodeficiency (CVID) and have been implicated in lymphoma pathogenesis. It regulates gene expression by translocation to the nucleus upon activation, but is normally sequestered in the cytoplasm.
- Other names
- CVID10H2TF1LYT-10LYT10NF-kB2p100p49/p100p52
02
Mechanism of action
Modulation of NF-κB signaling pathway through interference with dimerization, phosphorylation, or DNA binding.
03
Biological functions
Transcription regulationImmune responseInflammationCell survivalApoptosis regulation
04
Disease associations
Common Variable Immunodeficiency (CVID)LymphomaImmunodeficiencyEndocrinopathy
05
Safety considerations
Potential for broad immunosuppressionRisk of opportunistic infectionsPossible development of resistanceOff-target effects due to interactions with other NF-κB family members
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