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Nuclear Factor Kappa B Subunit RelA (NF-κB p65)
- Target
- NF-κB p65
- Molecular classification
- Transcription factor
01
Overview
NF-κB p65, also known as RelA, is a key subunit of the NF-κB family of transcription factors. It plays a central role in regulating immune response, inflammation, cell proliferation, apoptosis, and various other cellular processes. Under resting conditions, it is sequestered in the cytoplasm by IκB inhibitors. Upon stimulation, IκBs are phosphorylated and degraded, allowing p65-containing dimers to translocate into the nucleus and regulate target gene expression. Aberrant activation contributes to various diseases.
- Other names
- RelAv-rel avian reticuloendotheliosis viral oncogene homolog ANFKB3
02
Mechanism of action
Inhibition of NF-κB p65 nuclear translocation or DNA binding; modulation of post-translational modifications.
03
Biological functions
Immune responseInflammationCell survival/apoptosisCell proliferationCell deathCellular metabolismChemotaxisRegulation of gene expression
04
Disease associations
CancerInflammationNeurodegenerative diseaseAutoimmune disordersChronic inflammatory diseases
05
Safety considerations
Potential for broad immunosuppressionOff-target effects on other signaling pathways
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