Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)-mediated transcription pathway (NF-κB pathway)

The NFκB-mediated transcription pathway is a crucial cellular signaling cascade that regulates the activity of the NF-κB family of transcription factors. It controls gene expression in response to various stimuli, including inflammatory signals, stress, cytokines, free radicals, and pathogens. Activation leads to the translocation of NF-κB dimers into the nucleus, where they bind DNA and regulate the transcription of genes involved in inflammation, immunity, cell survival, and proliferation. Dysregulation of this pathway is implicated in cancer and chronic inflammatory diseases.

Other names

NFκB pathwayNF-kB signaling pathwayNF-kappaB pathwayNF-kappa B signaling pathwayNFkB mediated transcription

Varies depending on the specific drug; examples include inhibition of IKK, inhibition of proteasomal degradation of IκB, inhibition of NF-κB DNA binding, and reduction of upstream activating signals.