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Nuclear factor kappa-light-chain-enhancer of activated B cells p65 subunit (NF-κB p65 or RELA)
- Target
- NF-κB p65 or RELA
- Molecular classification
- Transcription factor
01
Overview
The Nuclear factor kappa-light-chain-enhancer of activated B cells p65 subunit, also known as RELA or p65, is a crucial component of the NF-κB transcription factor complex. It plays a central role in regulating immune responses, inflammation, cell growth, and survival. NF-κB is activated by a wide range of stimuli, including cytokines, stress, and bacterial or viral antigens. The p65 subunit forms heterodimers with other NF-κB subunits, such as p50, to translocate to the nucleus and activate gene transcription. Its dysregulation is associated with various diseases, including cancer and inflammatory disorders.
- Other names
- RELAp65Nuclear factor NF-kappa-B p65 subunit
02
Mechanism of action
Inhibition of NF-κB signaling pathway, which can reduce inflammation and immune responses.
03
Biological functions
Immune responseInflammationCell proliferationApoptosisSignal transduction
04
Disease associations
CancerInflammationCardiovascular diseaseNeurodegenerative disease
05
Safety considerations
Potential for immunosuppression and increased susceptibility to infections.
06
Interacting drugs
Various anti-inflammatory and immunomodulatory drugs, though specific drugs are not listed here.
07
Biomarkers
None specifically listed, but NF-κB activity can be monitored through downstream gene expression.
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