Nuclear factor kappa-light-chain-enhancer of activated B cells subunit p65 (NF-κB p65 or RELA)

Nuclear factor kappa-light-chain-enhancer of activated B cells subunit p65 (NF-κB p65 or RELA) is a transcription factor crucial for immune responses, inflammation, cell survival, and proliferation. It is part of the NF-κB complex, which is involved in various signaling pathways and is activated by diverse stimuli such as cytokines, stress, and bacterial or viral antigens. Misregulation of NF-κB has been linked to cancer, autoimmune diseases, and inflammatory conditions.

Other names

Transcription factor p65Nuclear factor NF-kappa-B p65 subunitNF-kappa B p65 SubunitRELAv-Rel reticuloendotheliosis viral oncogene homolog A

Drugs targeting NF-κB p65 typically work by inhibiting its activity, which can reduce inflammation and immune response.