Target intelligence / Profile preview

Nuclear factor kappa-light-chain-enhancer of activated B cells subunit RelB (RelB)

Target: RelB
Molecular classification: Transcription factor, NF-κB/Rel family

Overview

RelB is a transcription factor and a member of the NF-κB family, playing a crucial role in immune responses, inflammation, cell survival, and development. It functions as both an activator and repressor of gene expression and is particularly important in the non-canonical NF-κB signaling pathway. Dysregulation of RelB has been linked to inflammatory diseases and cancer.

Other names: c-RelBI-Rel

Biological functions

Immune regulationLymphoid organogenesisInflammatory responseRegulation of gene expressionCell survivalCell developmentLymphocyte trafficking

Disease associations

Inflammatory diseasesCancer (context-dependent)Autoimmune diseases

Safety considerations

Potential for off-target effects due to broad role in immune regulationContext-dependent effects on tumor progression/suppression

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