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Target intelligence / Profile preview
Nuclear factor kappa-light-chain-enhancer of activated B cells subunit RelB (RelB)
- Target
- RelB
- Molecular classification
- Transcription factor, NF-κB/Rel family
01
Overview
RelB is a transcription factor and a member of the NF-κB family, playing a crucial role in immune responses, inflammation, cell survival, and development. It functions as both an activator and repressor of gene expression and is particularly important in the non-canonical NF-κB signaling pathway. Dysregulation of RelB has been linked to inflammatory diseases and cancer.
- Other names
- c-RelBI-Rel
02
Biological functions
Immune regulationLymphoid organogenesisInflammatory responseRegulation of gene expressionCell survivalCell developmentLymphocyte trafficking
03
Disease associations
Inflammatory diseasesCancer (context-dependent)Autoimmune diseases
04
Safety considerations
Potential for off-target effects due to broad role in immune regulationContext-dependent effects on tumor progression/suppression
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