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Target intelligence / Profile preview
Nuclear factor NF-kappa-B p100 subunit (NF-κB2)
- Target
- NF-κB2
- Molecular classification
- Transcription factor
01
Overview
Nuclear factor NF-kappa-B p100 subunit, encoded by the NFKB2 gene, is a key regulator of immune responses, inflammation, and cell survival. It exists as a precursor protein (p100) that is processed into the active transcription factor p52. NF-κB2 can function as both a transcriptional activator and repressor. Mutations in NFKB2 are associated with immunodeficiency syndromes like CVID and DAVID syndrome, and chromosomal rearrangements involving this locus are linked to B-cell lymphomas.
- Other names
- NFKB2p100p52
02
Mechanism of action
NF-κB2/p100 protein can act both as a transcriptional activator or repressor depending on its dimerization partner, regulating target gene expression. Also functions as an inhibitor by sequestering other NF-kappa-B subunits in the cytoplasm.
03
Biological functions
Immune responseInflammationCell survivalApoptosisTranscriptional regulation
04
Disease associations
Common Variable Immunodeficiency (CVID)DAVID syndromeB-cell lymphomaImmunodeficiency
05
Safety considerations
Potential for broad effects on immune and inflammatory responses due to the pleiotropic nature of NF-κB signaling.Chromosomal rearrangements involving NFKB2 may contribute to malignancy development in B-cell lymphomas.
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