Nuclear factor NF-kappa-B p52 subunit (p52)

The Nuclear factor NF-kappa-B p52 subunit (p52) is a key transcription factor in the non-canonical NF-kappaB signaling pathway, produced by the site-specific proteolysis of its precursor protein, p100 (NFKB2). This pathway is distinct from the canonical NF-kappaB pathway and is primarily activated by a subset of TNF receptor superfamily members, such as BAFFR, CD40, and RANK, which lead to the stabilization of NF-kappaB-inducing kinase (NIK) and subsequent p100 processing. p52 plays essential roles in biological processes including lymphoid organ development, B-cell maturation, and the regulation of the circadian clock. In the context of disease, aberrant p52 activity is linked to various cancers, such as prostate cancer and multiple myeloma, where it drives cell proliferation, survival, and resistance to conventional therapies. Therapeutic targeting of p52 involves the use of small molecules to disrupt its interactions with co-factors like the androgen receptor, peptides to block its nuclear import, and inhibitors of upstream regulators like NIK and the proteasome. Additionally, p52 serves as a significant biomarker for disease progression and treatment response in several cancers, reflecting its central role in oncogenic signaling and immune evasion.

Other names

NFKB2p100LYT-10DNA-binding factor KBF2H2TF1Lymphocyte translocation chromosome 10 proteinNuclear factor of kappa light polypeptide gene enhancer in B-cells 2Oncogene Lyt-10

Inhibition of p100 processing to p52; Inhibition of p52 nuclear translocation; Inhibition of p52-protein interactions; Activation of the non-canonical NF-kappaB pathway for HIV latency reversal