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Target intelligence / Profile preview
Nuclear factor NF-kappa-B p65 subunit (RelA)
- Target
- RelA
- Molecular classification
- Transcription factor
01
Overview
The nuclear factor NF-kappa-B p65 subunit (RelA) is a key component of the NF-κB transcription factor complex. It plays a central role in regulating immune response, inflammation, cell growth, apoptosis, and tumorigenesis. RelA forms heterodimers most commonly with NFKB1/p50; this heterodimer is the most abundant form of active NF-kappa-B in cells. Upon stimulation, IκBs are degraded, and the p50/RelA dimer translocates to the nucleus to activate target gene expression. Dysregulation or constitutive activation of RELA/NF-kappa-B signaling has been implicated in chronic inflammatory diseases, autoimmune disorders, and cancer development/progression.
- Other names
- Transcription factor p65
02
Mechanism of action
Modulation of NF-κB signaling pathway, typically by inhibiting its activation or promoting its degradation.
03
Biological functions
Immune responseInflammationCell proliferationApoptosisCell survivalGene expression regulation
04
Disease associations
Chronic inflammatory diseasesAutoimmune disordersCancer developmentCancer progression
05
Safety considerations
Potential for broad immunosuppressionIncreased risk of infectionOff-target effects due to pleiotropic function of NF-κB
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