Nuclear fragile X mental retardation-interacting protein 2 (NUFIP2)

Nuclear fragile X mental retardation-interacting protein 2 (NUFIP2) is a ubiquitously expressed, non-canonical RNA-binding protein that interacts strongly with Roquin family proteins and is involved in post-transcriptional regulation of specific mRNA species, such as those encoding the T cell costimulatory molecule ICOS and the receptor OX40[1][3][4][5][6]. NUFIP2 localizes to cytoplasmic stress granules, nuclear bodies, and ribosomes, and its interaction with Roquin proteins enhances recognition and regulation of certain mRNA targets involved in immune cell function[1][2][3][4]. NUFIP2 also interacts with the fragile X mental retardation protein (FMRP), and competition between FMRP and Roquin for NUFIP2 likely influences mRNA decay pathways[1][3]. While associated genetically with neurodevelopmental and brain malformation syndromes, NUFIP2 is not recognized as a classical therapeutic target, nor are there approved drugs targeting its activity[4][5][6].

Other names

FMR1-interacting protein NUFIP2KIAA1321PIG182-FIPMGC117262182-FIPFIP-82NUFP2Cell proliferation-inducing gene 1 proteinFMRP-interacting protein 2Nuclear FMR1-interacting protein 282 kDa FMRP-interacting protein82-kD FMRP Interacting ProteinProliferation-inducing gene 1

None reported for direct drug targeting