Nuclear pore-associated protein 1 like (NPAP1L)

Nuclear pore-associated protein 1 like (NPAP1L) is a gene identified as a paralog of NPAP1, itself part of a family of retrogenes derived from the vertebrate nucleoporin gene POM121[2]. NPAP1 is a paternally imprinted gene present in the Prader-Willi syndrome region (15q11q13) in primates, with no functional mouse ortholog[2]. NPAP1L, however, is found in all placental mammals except rodents[2]. These genes are believed to have arisen from retrotransposition events of the POM121 gene, likely functioning as nucleoporin-like proteins, but both NPAP1 and NPAP1L lack the classical transmembrane domain of canonical nucleoporins like POM121[2]. There is no evidence in the current scientific literature that NPAP1L functions as a classical therapeutic target such as a receptor, enzyme, transporter, or traditional nucleoporin. Its biological function, clinical significance, druggability, and molecular interactions remain poorly defined. The canonical NPAP1 gene (not NPAP1L) is associated with Prader-Willi and Angelman syndromes and may be involved in nuclear pore complex biology, but NPAP1L’s role is speculative and uncharacterized[2][4]. Notes: - There is very limited to no evidence for NPAP1L being a well-validated protein, clinical drug target, or established molecular entity; it is mainly mentioned as an evolutionary artifact or retrogene of uncertain function[2]. - Most information in major resources focuses on NPAP1 or POM121 and not specifically on NPAP1L[2][4]. - If you are seeking a canonical molecular target with biological and pharmacological information, "NPAP1L" is likely incomplete or incorrect for such structured data requirements. - If your intent was the related human gene NPAP1 (nuclear pore-associated protein 1), more clinical and molecular information is available[2][4]; for NPAP1L, such data is lacking.

Other names

Nuclear pore-associated protein 1-likeNPAP1LC15orf2-related retrogenePOM121-related retrogene