Target intelligence / Profile preview

Nuclear pore complex-interacting protein family member B15 (NPIPB15)

Target
NPIPB15
Molecular classification
Other (protein-coding gene, poorly characterized protein; not classified as receptor, enzyme, transporter, channel, transcription factor, or histone-modifying enzyme)
01

Overview

Nuclear pore complex-interacting protein family member B15 (NPIPB15) is a human protein encoded by the NPIPB15 gene on chromosome 16. The protein is predicted to be located in the extracellular region and may function as a transcriptional repressor, but currently lacks confirmed molecular or cellular function[2][7][12]. It belongs to a larger poorly characterized family of nuclear pore complex-interacting proteins, and shares paralogy with NPIPB7[7]. There is no evidence to classify NPIPB15 among major molecular target classes such as receptors, enzymes, or ion channels. Although mRNA and protein are expressed in various human tissues and cancers, NPIPB15 is not recognized as a therapeutic target, disease biomarker, or druggable protein[7][8][12]. Most information remains computationally predicted or based on limited experimental data, and NPIPB15 is not referenced in drug targeting or major disease mechanisms.

Other names
NPIPL2LOC440348Nuclear pore complex-interacting protein family member B15Nuclear pore complex interacting protein family, member B15Nuclear pore complex interacting protein-like 2A-761H5.4
02

Biological functions

Predicted transcriptional repressor activity (unconfirmed; "might normally function as a transcriptional repressor")No definitive molecular or cellular function established
03

Disease associations

Other (No direct disease role established; a database entry notes possible involvement of NPIPB15 fusion proteins in tumorigenesis but evidence is weak and not primary)Some cancer tissue expression data exists, but there is no established functional or mechanistic disease link

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